This paper descries a new non-invasive method for diagnosis of breathing disorders based on adaptive-network-based fuzzy inference system (ANFIS). In this method, PetCO2, SpO2 and HR are chosen as inputs, and the breathing condition is selected as output ofANFIS. The inputs and output are then classified into fuzzy subsets by experts' knowledge. After, the fuzzy IF-THEN rules are built up according to the corresponding membership functions by set up of fuzzy subsets. The neural network was finally established and the membership functions and fuzzy rules were optimized by training. The results of experiment shows that ANFIS is more effective than BP Network regarding the diagnosis of breathing disorders.