Censored quantile regression for residual lifetimes

Lifetime Data Anal. 2012 Apr;18(2):177-94. doi: 10.1007/s10985-011-9212-2. Epub 2011 Dec 20.

Abstract

We propose a regression method that studies covariate effects on the conditional quantiles of residual lifetimes at a certain followup time point. This can be particularly useful in cancer studies, where more patients survive cancers initially and a patient's residual life expectancy is used to compare the efficacy of secondary or adjuvant therapies. The new method provides a consistent estimator that often exhibits smaller standard error in real and simulated examples, compared to the existing method of Jung et al. (2009). It also provides a simple empirical likelihood inference method that does not require estimating the covariance matrix of the estimator or resampling. We apply the new method to a breast cancer study (NSABP Protocol B-04, Fisher et al. (2002)) and estimate median residual lifetimes at various followup time points, adjusting for important prognostic factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Breast Neoplasms / mortality
  • Female
  • Humans
  • Life Tables*
  • Likelihood Functions
  • Mathematical Concepts
  • Models, Biological
  • Models, Statistical
  • Prognosis
  • Regression Analysis*
  • Survival Analysis