Polycomb regulates NF-κB signaling in cancer through miRNA

Iris Uribesalgo; Cecilia Ballaré; Luciano Di Croce

doi:10.1016/j.ccr.2011.12.019

Polycomb regulates NF-κB signaling in cancer through miRNA

Cancer Cell. 2012 Jan 17;21(1):5-7. doi: 10.1016/j.ccr.2011.12.019.

Authors

Iris Uribesalgo¹, Cecilia Ballaré, Luciano Di Croce

Affiliation

¹ Centre de Regulació Genòmica and UPF, Barcelona, Spain.

PMID: 22264783
DOI: 10.1016/j.ccr.2011.12.019

Abstract

The mechanisms leading to the constitutive activation of NF-κB in cancers and the pathways upstream and downstream of this activation are not fully understood. In this issue of Cancer Cell, Yamagishi et al. demonstrate that Polycomb-mediated silencing of miR-31 is implicated in the aberrant activation of NF-κB signaling in tumors.

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