R loops: lassoing DNA methylation at CpGi

Paula M Vertino; Paul A Wade

doi:10.1016/j.molcel.2012.03.014

R loops: lassoing DNA methylation at CpGi

Mol Cell. 2012 Mar 30;45(6):708-9. doi: 10.1016/j.molcel.2012.03.014.

Authors

Paula M Vertino¹, Paul A Wade

Affiliation

¹ Department of Radiation Oncology and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30307, USA. pvertin@emory.edu

PMID: 22464440
DOI: 10.1016/j.molcel.2012.03.014

Abstract

In this issue of Molecular Cell, Ginno et al. (2012) describe unusual sequence features at promoter CpG islands that can lead to formation of persistent RNA-DNA hybrids (R loops), which are proposed to prevent genomic DNA methylation.

Publication types

Comment

Grants and funding

R01 CA132065/CA/NCI NIH HHS/United States