LHX2 deregulation by juxtaposition with the IGH locus in a pediatric case of chronic myeloid leukemia in B-cell lymphoid blast crisis

Leuk Res. 2012 Sep;36(9):e195-8. doi: 10.1016/j.leukres.2012.05.013. Epub 2012 Jun 22.

Authors

Nathalie Nadal, Elise Chapiro, Pascale Flandrin-Gresta, Sandrine Thouvenin, Christian Vasselon, Kheira Beldjord, Odile Fenneteau, Olivier Bernard, Lydia Campos, Florence Nguyen-Khac

PMID: 22727509
DOI: 10.1016/j.leukres.2012.05.013

No abstract available

Publication types

Case Reports
Letter

MeSH terms

B-Lymphocytes / pathology
Blast Crisis / genetics
Blast Crisis / pathology
Child
Chromosomes, Human, Pair 14 / genetics
Chromosomes, Human, Pair 9 / genetics
Gene Expression Regulation, Leukemic
Genes, Immunoglobulin Heavy Chain / genetics*
Genetic Loci / genetics
Humans
LIM-Homeodomain Proteins / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
Male
Transcription Factors / genetics*
Translocation, Genetic* / genetics
Translocation, Genetic* / physiology

Substances

LHX2 protein, human
LIM-Homeodomain Proteins
Transcription Factors