Methylation muscles into transcription factor silencing

Transcription. 2012 Sep-Oct;3(5):215-20. doi: 10.4161/trns.20914. Epub 2012 Sep 1.

Abstract

The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.

Keywords: G9a; PRC2; chromatin modifiers; differentiation; methylation; skeletal muscle; transcription; transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epigenomics
  • Humans
  • Methylation
  • Muscle Development / physiology*
  • Muscle, Skeletal / growth & development*
  • MyoD Protein / chemistry
  • MyoD Protein / physiology*

Substances

  • MyoD Protein