Angioneurotic orolingual oedema following thrombolysis in acute ischaemic stroke

BMJ Case Rep. 2010 Oct 21:2010:bcr0620103094. doi: 10.1136/bcr.06.2010.3094.

Abstract

Alteplase used for thrombolysis in ischaemic stroke may be complicated by orolingual acute angioedema (OAA), a rare but potentially life-threatening side effect. We report the case of a 32-year-old woman who over 24 h experienced OAA after thrombolysis for an acute ischaemic left hemispheric stroke. We discuss the pathophysiology of this rare phenomenon.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angioedema / chemically induced*
  • Angioedema / diagnosis
  • Female
  • Fibrinolytic Agents / adverse effects*
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Stroke / drug therapy*
  • Tissue Plasminogen Activator / adverse effects*
  • Tissue Plasminogen Activator / therapeutic use
  • Tongue Diseases / chemically induced*
  • Tongue Diseases / diagnosis

Substances

  • Fibrinolytic Agents
  • Tissue Plasminogen Activator