Uncommon leukemic case of anaplastic large cell lymphoma diagnosed through a typical chromosomal abnormality t(2;5) with a null phenotype and aberrant expression of NG2 and CD13

Bratisl Lek Listy. 2012;113(7):404-8. doi: 10.4149/bll_2012_091.

Abstract

Anaplastic large cell lymphoma represents approximately 10-15 % of pediatric non-Hodgkin lymphomas. Leukemic presentation is very rare, and in particular, the null phenotype ALCL without typical anaplastic morphology together with aberrant expression of CD13 and/or CD11b represents a diagnostic challenge. We report a case of a 9 year-old boy with leukemic presentation of ALCL with the typical translocation t(2;5)(p23;q35); in this patient, the only positive antigens identified by immunophenotyping were CD13, NG2 HLA-DR, and CD38. To our knowledge, aberrant expression of NG2 has never been reported in ALCL cases (Tab. 1, Fig. 6, Ref. 20).

Publication types

  • Case Reports

MeSH terms

  • Antigens / metabolism*
  • CD13 Antigens / metabolism*
  • Child
  • Chromosomes, Human, Pair 2
  • Chromosomes, Human, Pair 5
  • Humans
  • Immunophenotyping*
  • Lymphoma, Large-Cell, Anaplastic / diagnosis*
  • Lymphoma, Large-Cell, Anaplastic / genetics
  • Lymphoma, Large-Cell, Anaplastic / immunology
  • Male
  • Proteoglycans / metabolism*
  • Translocation, Genetic*

Substances

  • Antigens
  • Proteoglycans
  • chondroitin sulfate proteoglycan 4
  • CD13 Antigens