Higher soluble P-selectin is associated with chronic venous insufficiency: the San Diego Population Study

Thromb Res. 2012 Nov;130(5):716-9. doi: 10.1016/j.thromres.2012.07.012. Epub 2012 Aug 12.

Abstract

Introduction: P-selectin is a cell adhesion molecule shown to play a role in venous thromboembolism. We evaluated whether higher P-selectin is associated with chronic venous insufficiency (CVI).

Materials and methods: In a cohort of 2408 participants, the San Diego Population Study, peripheral venous disease was established by symptoms, clinical examination, and ultrasound. We measured P-selectin in a subsample of 352 CVI cases frequency matched to controls. Cases included four hierarchical groups of increasing severity of CVI.

Results: The association of P-selectin with CVI considering all cases was weak, with an age, race and sex-adjusted odds ratio (OR) of 1.3 (95% CI 1.0-2.2) for values in the 3rd versus 1st tertile. The OR for cases in the two most severe groups was 2.3 (95% CI 1.2-4.2). Addition of body mass index to the model reduced this OR to 1.9 (95% CI 1.0-3.6).

Conclusions: Higher circulating P-selectin was associated with more severe CVI, but not CVI overall. Results support that platelet and endothelial cell activation may be involved in the pathogenesis of CVI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • California / epidemiology
  • Case-Control Studies
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • P-Selectin / metabolism*
  • Risk Factors
  • Venous Insufficiency / epidemiology
  • Venous Insufficiency / metabolism*

Substances

  • P-Selectin