Concomitant use of pazopanib and simvastatin increases the risk of transaminase elevations in patients with cancer

Ann Oncol. 2012 Sep;23(9):2470-2471. doi: 10.1093/annonc/mds249.

Authors

C F Xu¹, Z Xue², N Bing², K S King², L A McCann³, P L de Souza⁴, V L Goodman⁵, C F Spraggs¹, V E Mooser², L N Pandite⁵

Affiliations

¹ Department of Genetics, GlaxoSmithKline Research and Development, Stevenage, UK.
² Department of Genetics, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia.
³ Department of Clinical Statistics, GlaxoSmithKline Research and Development, Philadelphia, USA.
⁴ Department of Medical Oncology, University of Western Sydney School of Medicine, Sydney, Australia.
⁵ Department of Oncology, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia, United States.

PMID: 22918879
DOI: 10.1093/annonc/mds249

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters / genetics
Alanine Transaminase / blood*
Anticholesteremic Agents / adverse effects
Anticholesteremic Agents / pharmacology*
Anticholesteremic Agents / therapeutic use
Antineoplastic Agents / adverse effects
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use
Chemical and Drug Induced Liver Injury / epidemiology
Chemical and Drug Induced Liver Injury / genetics
Clinical Trials as Topic
Drug Interactions
Humans
Hypercholesterolemia / blood
Hypercholesterolemia / drug therapy
Incidence
Indazoles
Neoplasm Proteins / genetics
Neoplasms / blood*
Neoplasms / drug therapy
Polymorphism, Single Nucleotide
Pyrimidines / adverse effects
Pyrimidines / pharmacology*
Pyrimidines / therapeutic use
Reference Values
Simvastatin / adverse effects
Simvastatin / pharmacology*
Simvastatin / therapeutic use
Sulfonamides / adverse effects
Sulfonamides / pharmacology*
Sulfonamides / therapeutic use

Substances

ABCG2 protein, human
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters
Anticholesteremic Agents
Antineoplastic Agents
Indazoles
Neoplasm Proteins
Pyrimidines
Sulfonamides
pazopanib
Simvastatin
Alanine Transaminase