Prevalence of human leukocyte antigen-B*5701 among HIV-infected children in Thailand and Cambodia: implications for abacavir use

Pediatr Infect Dis J. 2013 Mar;32(3):252-3. doi: 10.1097/INF.0b013e3182745dba.

Abstract

Human leukocyte antigen (HLA)-B*5701 allele is associated with abacavir hypersensitivity. Limited data among Asians showed lower rates of HLA-B*5701 compared with Caucasians. In 296 children with HIV in Thailand and Cambodia, the prevalence of HLA-B*5701 was 4.0% (95% confidence interval: 1.6-8.0%) among Thai and 3.4% (95% confidence interval: 0.9-8.5%) among Cambodian children. HLA-B*5701 carriage is not uncommon among Thai and Cambodian children; it is close to the prevalence found in European and higher than the prevalence found in East Asian and African studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cambodia
  • Child
  • Child, Preschool
  • Dideoxynucleosides / adverse effects*
  • Dideoxynucleosides / therapeutic use*
  • Drug Hypersensitivity / genetics*
  • Female
  • Gene Frequency
  • HIV Infections / drug therapy*
  • HLA-B Antigens / genetics*
  • Humans
  • Infant
  • Male
  • Prevalence
  • Thailand

Substances

  • Dideoxynucleosides
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • abacavir