CD133 in the selection of epidermal stem cells in mice: steps in the right direction

J Invest Dermatol. 2012 Nov;132(11):2492-4. doi: 10.1038/jid.2012.322.

Abstract

Charruyer and colleagues (this issue) report two significant advances to the field of cutaneous keratinocyte stem cells: a pair of new selectable markers that recognize a subset of α6(+)CD34(+) label-retaining cells, and an in vivo limiting dilution assay for keratinocyte stem cells with long-term repopulating ability. This work has important implications for keratinocyte stem cell identification and assay, as well as for the identification of target cells in non-melanoma skin cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • AC133 Antigen
  • Animals
  • Antigens, CD / metabolism*
  • Epidermal Cells*
  • Epidermis / physiology*
  • Glycoproteins / metabolism*
  • Keratinocytes / cytology*
  • Mice
  • Multipotent Stem Cells / cytology*
  • Peptides / metabolism*

Substances

  • AC133 Antigen
  • Antigens, CD
  • Glycoproteins
  • Peptides
  • Prom1 protein, mouse