GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations

Leukemia. 2013 Jul;27(7):1588-92. doi: 10.1038/leu.2012.346. Epub 2012 Nov 28.

Authors

M Perugini, D G Iarossi, C H Kok, N Cummings, S M Diakiw, A L Brown, S Danner, P Bardy, L Bik To, A H Wei, I D Lewis, R J D'Andrea

PMID: 23187294
DOI: 10.1038/leu.2012.346

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Cell Cycle Proteins / genetics*
DNA (Cytosine-5-)-Methyltransferases / genetics*
DNA Methylation / physiology
DNA Methyltransferase 3A
Female
Genetic Testing
Humans
Isocitrate Dehydrogenase / genetics*
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / mortality*
Male
Middle Aged
Mutation / genetics
Nuclear Proteins / genetics*
Young Adult

Substances

Cell Cycle Proteins
DNMT3A protein, human
GADD45A protein, human
Nuclear Proteins
IDH2 protein, human
Isocitrate Dehydrogenase
IDH1 protein, human
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A