Making limbs from fins

Igor Schneider; Neil H Shubin

doi:10.1016/j.devcel.2012.11.011

Making limbs from fins

Dev Cell. 2012 Dec 11;23(6):1121-2. doi: 10.1016/j.devcel.2012.11.011.

Authors

Igor Schneider¹, Neil H Shubin

Affiliation

¹ Instituto de Ciencias Biologicas, Universidade Federal do Para, 66075 Belem, Brazil. ischneider@ufpa.br

PMID: 23237946
DOI: 10.1016/j.devcel.2012.11.011

Abstract

Our limbs evolved from fish fins as vertebrates colonized aquatic shallows and land. If we understood the genetics underlying this transition, could we build a limb on a fish? In this issue of Developmental Cell, Freitas et al. (2012) show that boosting Hoxd13 expression can bring zebrafish one step closer to terra firma.

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