A facile synthesis, antibacterial activity of pulvinone and its derivatives

Bioorg Med Chem Lett. 2013 Feb 1;23(3):737-9. doi: 10.1016/j.bmcl.2012.11.090. Epub 2012 Dec 1.

Abstract

Pulvinone and several 3-fluoro-4-morpholino substituted pulvinone derivatives were synthesized in five steps from a common precursor, phenyl acetic acid. Most of synthetic morpholine substituted pulvinones showed inhibitory activity against Esherichia coli. For the first time, the inhibition of pulvinone and its derivatives against Gram-negative bacteria was reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / pharmacology
  • Acetamides / chemistry*
  • Acetamides / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Benzylidene Compounds / chemistry*
  • Benzylidene Compounds / pharmacology*
  • Gram-Negative Bacteria / drug effects*
  • Linezolid
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Oxazolidinones / chemistry*
  • Oxazolidinones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Benzylidene Compounds
  • Oxazolidinones
  • Linezolid
  • 4-Butyrolactone
  • pulvinone