The longevity of sirtuins

Cell Rep. 2012 Dec 27;2(6):1473-4. doi: 10.1016/j.celrep.2012.12.004.

Abstract

Controversy has recently arisen over the role of sirtuins in metazoan aging. In this issue of Cell Reports, Banerjee et al. demonstrate that Drosophila Sir2 is necessary for life span extension in response to dietary restriction and that its overexpression in the fat body increases the life span.

Publication types

  • Comment

MeSH terms

  • Animals
  • Diet*
  • Drosophila Proteins / metabolism*
  • Fat Body / metabolism*
  • Histone Deacetylases / metabolism*
  • Longevity / physiology*
  • Sirtuins / metabolism*

Substances

  • Drosophila Proteins
  • Sirt2 protein, Drosophila
  • Sirtuins
  • Histone Deacetylases