Group analysis of resting-state fMRI by hierarchical Markov random fields

Med Image Comput Comput Assist Interv. 2012;15(Pt 3):189-96. doi: 10.1007/978-3-642-33454-2_24.

Abstract

Identifying functional networks from resting-state functional MRI is a challenging task, especially for multiple subjects. Most current studies estimate the networks in a sequential approach, i.e., they identify each individual subject's network independently to other subjects, and then estimate the group network from the subjects networks. This one-way flow of information prevents one subject's network estimation benefiting from other subjects. We propose a hierarchical Markov random field model, which takes into account both the within-subject spatial coherence and between-subject consistency of the network label map. Both population and subject network maps are estimated simultaneously using a Gibbs sampling approach in a Monte Carlo expectation maximization framework. We compare our approach to two alternative groupwise fMRI clustering methods, based on K-means and normalized Cuts, using both synthetic and real fMRI data. We show that our method is able to estimate more consistent subject label maps, as well as a stable group label map.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Algorithms*
  • Brain / physiology*
  • Brain Mapping / methods*
  • Female
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Markov Chains
  • Nerve Net / physiology*
  • Reproducibility of Results
  • Rest / physiology*
  • Sensitivity and Specificity