Terahertz time-domain spectroscopy of glucose and uric Acid

J Biol Phys. 2003 Jun;29(2-3):117-21. doi: 10.1023/A:1024476322147.

Abstract

We report the use ofterahertz time-domain spectroscopy for thestudy of two therapeutic bio-molecules:glucose and uric acid. Terahertztransmission spectra of crystalline samplesof both molecules were measured between 0.1-3.0 THz using an evacuated spectroscopysystem. We propose that the stereo-isomersof glucose show spectral featuresoriginating from intermolecular vibrationalmodes, as do uric acid and its derivativemolecule, allantoin. In addition, wepresent a full temperature dependence ofthe terahertz absorption of L-glucose.

Keywords: Glucose; intermolecular; temperature dependent absorption; terahertz; time-domain spectroscopy; uric acid.