Application and clinical utility of the Glasgow Coma Scale over time: a study employing the NIDRR traumatic brain injury model systems database

J Head Trauma Rehabil. 2014 Sep-Oct;29(5):400-6. doi: 10.1097/HTR.0b013e31828a0a45.

Abstract

Objective: To examine possible changes in Glasgow Coma Scale (GCS) scores related to changes in emergency management, such as intubation and chemical paralysis, and the potential impact on outcome prediction.

Participants: 10 228 patients from the Traumatic Brain Injury Model Systems national database.

Design: Retrospective study examining 5-year epochs from 1987 to 2012.

Main measures: GCS score assessed in the Emergency Department (GCS scores for intubated, but not paralyzed, patients were estimated with a formula using 2 of the 3 GCS components), Outcome: Functional Independence Measure (FIM) assessed at rehabilitation admission.

Results: The rate of intubation prior to GCS scoring averaged 43% and did not increase across time. However, a clear increase over time was observed in the use of paralytics or heavy sedatives, with 27% of patients receiving this intervention in the most recent epoch. Estimated GCS scores classified 69% of intubated patients as severely brain injured and 8% as mildly injured. The GCS accounted for a modest, yet consistent, amount of variability (approximately 5%-7%) in FIM scores during most epochs.

Conclusions: Given the frequency of intubation and/or paralysis following brain injury in this sample, estimating GCS or exploring other means to gauge injury severity is beneficial, particularly because a portion likely did not sustain severe brain injury. There is no evidence for declining predictive utility of the GCS over time.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Injuries / diagnosis*
  • Databases, Factual
  • Disability Evaluation
  • Emergency Service, Hospital
  • Female
  • Glasgow Coma Scale*
  • Humans
  • Hypnotics and Sedatives / therapeutic use
  • Intubation, Intratracheal
  • Linear Models
  • Male
  • Middle Aged
  • Muscle Relaxants, Central / therapeutic use
  • Retrospective Studies
  • Young Adult

Substances

  • Hypnotics and Sedatives
  • Muscle Relaxants, Central