Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?

Circ Res. 2013 Mar 15;112(6):969-76; discussion 976. doi: 10.1161/CIRCRESAHA.112.300567.

Abstract

This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questions: Which clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using iPSC-CM to personalize antiarrhythmic drug therapy? The review also discusses the pros and cons of using the iPSC-CM technology for modeling specific genetic arrhythmia disorders, such as long QT syndrome, Brugada Syndrome, or Catecholaminergic Polymorphic Ventricular Tachycardia.

Publication types

  • Research Support, N.I.H., Extramural
  • Review
  • Comment

MeSH terms

  • Arrhythmias, Cardiac / pathology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Myocytes, Cardiac / cytology*