Mitochondrial fission: rings around the organelle

Curr Biol. 2013 Apr 8;23(7):R279-81. doi: 10.1016/j.cub.2013.02.042.

Abstract

Mitochondria form a dynamic network in which organelles fuse or divide in response to metabolic changes or cellular stress. New work shows that mitochondria do not divide in isolation from other cellular structures. Rather, they carry out this process in partnership with the endoplasmic reticulum and actin filaments.

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Dynamins
  • Endoplasmic Reticulum / metabolism*
  • Formins
  • GTP Phosphohydrolases / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Microfilament Proteins / metabolism*
  • Microtubule-Associated Proteins / metabolism*
  • Mitochondrial Dynamics / physiology*
  • Mitochondrial Proteins / metabolism*
  • Multiprotein Complexes / metabolism*
  • Multiprotein Complexes / physiology
  • Yeasts

Substances

  • Formins
  • INF2 protein, human
  • Membrane Proteins
  • Mff protein, human
  • Microfilament Proteins
  • Microtubule-Associated Proteins
  • Mitochondrial Proteins
  • Multiprotein Complexes
  • GTP Phosphohydrolases
  • DNM1L protein, human
  • Dynamins