New balance in pluripotency: reprogramming with lineage specifiers

Uri Ben-David; Jonathan Nissenbaum; Nissim Benvenisty

doi:10.1016/j.cell.2013.04.051

New balance in pluripotency: reprogramming with lineage specifiers

Cell. 2013 May 23;153(5):939-40. doi: 10.1016/j.cell.2013.04.051.

Authors

Uri Ben-David¹, Jonathan Nissenbaum, Nissim Benvenisty

Affiliation

¹ Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

PMID: 23706730
DOI: 10.1016/j.cell.2013.04.051

Abstract

Induction of pluripotency in somatic cells has been achieved by myriad combinations of transcription factors that belong to the core pluripotency circuitry. In this issue, Shu et al. report reprogramming with lineage specifiers, lending support to the view of the pluripotent state as a fine balance between competing differentiation forces.

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MeSH terms

Animals
Induced Pluripotent Stem Cells / cytology*
Induced Pluripotent Stem Cells / metabolism*
Transcription Factors / metabolism*

Substances

Transcription Factors