18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma

Clin Imaging. 2013 Sep-Oct;37(5):942-6. doi: 10.1016/j.clinimag.2013.01.004. Epub 2013 Jul 1.

Abstract

Objective: We retrospectively investigate the prevalence of gynecomastia as false-positive 2-[18F]fluoro-2-deoxy-d-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging in patients with hepatocellular carcinoma (HCC).

Methods: Among the 127 male HCC patients who underwent 18F-FDG PET/CT scan, the 18FDG uptakes at the bilateral breasts in 9 patients with gynecomastia were recorded as standard uptake value (SUVmax) and the visual interpretation in both early and delayed images.

Results: The mean early SUVmax was 1.58/1.57 (right/left breast) in nine gynecomastia patients. The three patients with early visual score of 3 had higher early SUVmaxs.

Conclusion: Gynecomastia is a possible cause of false-positive uptake on 18F-FDG PET/CT images.

Keywords: (18)FDG PET/CT; Gynecomastia; Hepatocellular carcinoma; SUVmax.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carcinoma, Hepatocellular / complications*
  • Carcinoma, Hepatocellular / surgery
  • Fluorodeoxyglucose F18
  • Gynecomastia / complications
  • Gynecomastia / diagnosis*
  • Gynecomastia / diagnostic imaging
  • Humans
  • Liver Neoplasms / complications*
  • Liver Neoplasms / surgery
  • Liver Transplantation
  • Male
  • Middle Aged
  • Positron-Emission Tomography / methods
  • Retrospective Studies
  • Tomography, X-Ray Computed

Substances

  • Fluorodeoxyglucose F18