Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil)

Ki Hyun Kim; Sang Un Choi; Mi Won Son; Sang Zin Choi; Jon Clardy; Kang Ro Lee

doi:10.1021/np400326e

Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil)

J Nat Prod. 2013 Jul 26;76(7):1376-9. doi: 10.1021/np400326e. Epub 2013 Jul 1.

Authors

Ki Hyun Kim¹, Sang Un Choi, Mi Won Son, Sang Zin Choi, Jon Clardy, Kang Ro Lee

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

PMID: 23815260
DOI: 10.1021/np400326e

Abstract

Pharbinilic acid (1), the first naturally occurring allogibberic acid, was isolated from ethanol extracts of morning glory (Pharbitis nil) seeds. Its absolute configuration was determined by NOESY NMR and ECD experiments. Compound 1 showed weak cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cells and weakly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 microglia cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / isolation & purification*
Heterocyclic Compounds, 4 or More Rings / pharmacology
Ipomoea nil / chemistry
Lipopolysaccharides / pharmacology
Microglia / drug effects
Molecular Structure
Nitric Oxide / biosynthesis
Republic of Korea
Seeds / chemistry

Substances

Antineoplastic Agents, Phytogenic
Heterocyclic Compounds, 4 or More Rings
Lipopolysaccharides
pharbinilic acid
Nitric Oxide