Oral exposure to cylindrospermopsin in pregnant rats: reproduction and foetal toxicity studies

Toxicon. 2013 Nov:74:127-9. doi: 10.1016/j.toxicon.2013.08.051. Epub 2013 Aug 27.

Abstract

Cylindrospermopsin (CYN) induces toxicity in pregnant mice when administered intraperitoneally. This study investigated whether oral exposure to CYN (0.03, 0.3 and 3 μg/kg) during pregnancy causes toxic effects and impairs gestation in rats. The results of reproductive performance and teratology studies were similar between the control and experimental dams. Our findings suggest that CYN consumption within the guideline values for drinking water is not able to promote foetal toxicity or alterations in rat reproductive performance.

Keywords: Cylindrospermopsin; Foetus; Rat; Reproduction; Toxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Alkaloids
  • Animals
  • Bacterial Toxins
  • Cyanobacteria Toxins
  • Drug Evaluation, Preclinical
  • Female
  • Fetus / drug effects*
  • Fetus / metabolism
  • Maternal Exposure / adverse effects*
  • Pregnancy
  • Rats
  • Reproduction / drug effects*
  • Toxicity Tests, Acute
  • Uracil / administration & dosage
  • Uracil / analogs & derivatives*
  • Uracil / toxicity

Substances

  • Alkaloids
  • Bacterial Toxins
  • Cyanobacteria Toxins
  • cylindrospermopsin
  • Uracil