Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor

J Invest Dermatol. 2014 Apr;134(4):1143-1145. doi: 10.1038/jid.2013.472. Epub 2013 Nov 8.
No abstract available

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Aminocaproic Acid / chemistry
  • Antimicrobial Cationic Peptides / metabolism
  • Aprotinin / chemistry
  • Cathelicidins
  • Double-Blind Method
  • Female
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Inflammation
  • Kallikreins / metabolism
  • Male
  • Middle Aged
  • Peptide Hydrolases / metabolism
  • Pilot Projects
  • Rosacea / drug therapy*
  • Rosacea / enzymology*
  • Serine Proteases / metabolism*
  • Serine Proteinase Inhibitors / administration & dosage
  • Serine Proteinase Inhibitors / therapeutic use*
  • Skin / enzymology
  • Treatment Outcome
  • Trypsin / chemistry

Substances

  • Antimicrobial Cationic Peptides
  • Serine Proteinase Inhibitors
  • Aprotinin
  • Peptide Hydrolases
  • Serine Proteases
  • KLK5 protein, human
  • Kallikreins
  • Trypsin
  • Aminocaproic Acid
  • Cathelicidins