A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease

Chem Commun (Camb). 2014 May 25;50(40):5301-3. doi: 10.1039/c3cc48473d. Epub 2013 Dec 10.

Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / chemistry*
  • Amyloid beta-Peptides / metabolism
  • Chelating Agents / metabolism
  • Coordination Complexes
  • Copper / chemistry*
  • Copper / metabolism
  • Humans
  • Oxidative Stress / drug effects*
  • Small Molecule Libraries / pharmacology*
  • Zinc / chemistry*
  • Zinc / metabolism

Substances

  • Amyloid beta-Peptides
  • Chelating Agents
  • Coordination Complexes
  • Small Molecule Libraries
  • Copper
  • Zinc