["Growing teratoma syndrome": an unrecognized complication of treated germ cell tumors of the testis]

Ann Pathol. 2013 Dec;33(6):402-5. doi: 10.1016/j.annpat.2013.10.020. Epub 2013 Nov 20.
[Article in French]

Abstract

"Growing teratoma syndrome" is a rare and often unrecognized complication of nonseminomatous germ cell tumors of the testis. It is defined by enlarging residual masses, frequently retroperitonal, composed exclusively by teratoma, during the course of chemotherapy. Complications of this syndrome are due to masses compression. Malignant transformation is also possible. "Growing teratoma syndrome" has a good prognosis when cured by complete surgical excision of the tumoral masses. We report the case of a "growing teratoma syndrome" presenting as a retroperitoneal mass occurring in a patient previously treated by orchiectomy and chemotherapy for a nonseminomatous mixed germ cell tumors of the testis without teratomatous component.

Keywords: Growing teratoma syndrome; Masse résiduelle; Non seminomatous germ cell tumor; Residual mass; Teratoma; Tumeur germinale non séminomateuse; Tératome; « Growing teratoma syndrome ».

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carcinoma, Embryonal / drug therapy
  • Carcinoma, Embryonal / pathology*
  • Carcinoma, Embryonal / surgery
  • Choriocarcinoma / drug therapy
  • Choriocarcinoma / pathology*
  • Choriocarcinoma / surgery
  • Combined Modality Therapy
  • Disease Progression
  • Humans
  • Lymphatic Metastasis
  • Male
  • Neoplasm, Residual
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / pathology*
  • Neoplasms, Germ Cell and Embryonal / surgery
  • Orchiectomy
  • Prognosis
  • Retroperitoneal Neoplasms / diagnosis
  • Retroperitoneal Neoplasms / secondary*
  • Retroperitoneal Neoplasms / surgery
  • Syndrome
  • Teratoma / diagnosis
  • Teratoma / secondary*
  • Teratoma / surgery
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / pathology*
  • Testicular Neoplasms / surgery
  • Young Adult

Supplementary concepts

  • Nonseminomatous germ cell tumor