Contributions of B cells to lupus pathogenesis

Allison Sang; Ying-Yi Zheng; Laurence Morel

doi:10.1016/j.molimm.2013.11.013

Contributions of B cells to lupus pathogenesis

Mol Immunol. 2014 Dec;62(2):329-38. doi: 10.1016/j.molimm.2013.11.013. Epub 2013 Dec 12.

Authors

Allison Sang¹, Ying-Yi Zheng¹, Laurence Morel²

Affiliations

¹ Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
² Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: morel@ufl.edu.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Keywords: Autoimmunity; B cells; Lupus.

Publication types

Review

MeSH terms

Animals
Autoantibodies / immunology
B-Lymphocytes / immunology*
Humans
Immune Tolerance / immunology
Lupus Erythematosus, Systemic / immunology*
Lupus Erythematosus, Systemic / pathology*

Substances

Autoantibodies

Abstract

Publication types

MeSH terms

Substances

Grants and funding