A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions

Robin G Lerner; Claudia Petritsch

doi:10.1038/ncb2924

A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions

Nat Cell Biol. 2014 Mar;16(3):212-4. doi: 10.1038/ncb2924.

Authors

Robin G Lerner¹, Claudia Petritsch¹

Affiliation

¹ Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California, USA.

PMID: 24576899
PMCID: PMC5453176
DOI: 10.1038/ncb2924

Abstract

Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.

Publication types

Comment

MeSH terms

Adenocarcinoma / pathology*
Animals
Colorectal Neoplasms / pathology*
Female
Humans
MicroRNAs / genetics*
Mitosis*
Neoplastic Stem Cells / physiology*
Snail Family Transcription Factors
Transcription Factors / physiology*

Substances

MIRN146 microRNA, human
MicroRNAs
Snail Family Transcription Factors
Transcription Factors

Grants and funding

R01 CA164746/CA/NCI NIH HHS/United States