The Indian Consensus Document on cardiac biomarker

Indian Heart J. 2014 Jan-Feb;66(1):73-82. doi: 10.1016/j.ihj.2013.12.053.

Abstract

Despite recent advances, the diagnosis and management of heart failure evades the clinicians. The etiology of congestive heart failure (CHF) in the Indian scenario comprises of coronary artery disease, diabetes mellitus and hypertension. With better insights into the pathophysiology of CHF, biomarkers have evolved rapidly and received diagnostic and prognostic value. In CHF biomarkers prove as measures of the extent of pathophysiological derangement; examples include biomarkers of myocyte necrosis, myocardial remodeling, neurohormonal activation, etc. In CHF biomarkers act as indicators for the presence, degree of severity and prognosis of the disease, they may be employed in combination with the present conventional clinical assessments. These make the biomarkers feasible options against the present expensive measurements and may provide clinical benefits.

Keywords: Biomarkers; Brain natriuretic peptide; Heart failure; NT-proBNP.

Publication types

  • Consensus Development Conference
  • Review

MeSH terms

  • Biomarkers / blood
  • Consensus
  • Disease Management
  • Disease Progression
  • Galectin 3 / blood*
  • Heart Failure / blood*
  • Heart Failure / mortality*
  • Heart Failure / therapy
  • Humans
  • Monitoring, Physiologic / methods
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Survival Rate

Substances

  • Biomarkers
  • Galectin 3
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain