Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso; Francesco Maria Calabrese; Achille Iolascon; Erling Mellerup

doi:10.1016/j.cancergen.2014.02.004

Combinations of genetic data in a study of neuroblastoma risk genotypes

Cancer Genet. 2014 Mar;207(3):94-7. doi: 10.1016/j.cancergen.2014.02.004. Epub 2014 Feb 15.

Authors

Mario Capasso¹, Francesco Maria Calabrese², Achille Iolascon¹, Erling Mellerup³

Affiliations

¹ Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Naples, Italy; CEINGE (Centro Ingegneria Genetica) Advanced Biotechnologies, Naples, Italy.
² CEINGE (Centro Ingegneria Genetica) Advanced Biotechnologies, Naples, Italy.
³ Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Faculty of Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: mellerup@hotmail.com.

PMID: 24726319
DOI: 10.1016/j.cancergen.2014.02.004

Abstract

Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).

Keywords: Neuroblastoma; SNPs; combinations; data mining.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genotype
Humans
Neuroblastoma / genetics*
Polymorphism, Single Nucleotide