A new component of the Fraser complex

J Invest Dermatol. 2014 May;134(5):1192-1193. doi: 10.1038/jid.2013.514.

Abstract

In embryos, the Fraser complex (FC) mediates epithelial-connective tissue interactions. Loss of expression of FC components leads to Fraser syndrome (FS), in which cohesion of epithelial tissues and stroma is perturbed. Using zebrafish, Richardson et al. (this issue) identified the protein AMACO in the FC. We discuss the utility of zebrafish in determining FC functions and identifying FS targets.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Basement Membrane / metabolism*
  • Biomarkers, Tumor
  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins / genetics*
  • Extracellular Matrix Proteins / metabolism*
  • Female
  • Fraser Syndrome / metabolism*
  • Male
  • Zebrafish Proteins / genetics*
  • Zebrafish Proteins / metabolism*

Substances

  • Biomarkers, Tumor
  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins
  • VWA2 protein, zebrafish
  • Vwa2 protein, mouse
  • Zebrafish Proteins