Abstract
In vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by ZnCl2 with a 50% inhibitory concentration (IC50) of 15 μM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6')-Ib in cultures containing 8 μg/ml amikacin was significantly inhibited by the addition of 2 μM Zn(2+) in complex with the ionophore pyrithione (ZnPT).
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetyltransferases / antagonists & inhibitors*
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Acinetobacter baumannii / enzymology*
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Amikacin / pharmacology*
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Anti-Bacterial Agents / pharmacology
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Chlorides / pharmacology*
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Drug Resistance, Bacterial / drug effects
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Escherichia coli / enzymology*
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Ionophores / pharmacology
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Microbial Sensitivity Tests
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Pyridines / pharmacology
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Thiones / pharmacology
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Zinc Compounds / pharmacology*
Substances
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Anti-Bacterial Agents
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Chlorides
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Ionophores
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Pyridines
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Thiones
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Zinc Compounds
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pyrithione
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Amikacin
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zinc chloride
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Acetyltransferases
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aminoglycoside N(6')-acetyltransferase