Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore

Antimicrob Agents Chemother. 2014 Jul;58(7):4238-41. doi: 10.1128/AAC.00129-14. Epub 2014 May 12.

Abstract

In vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by ZnCl2 with a 50% inhibitory concentration (IC50) of 15 μM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6')-Ib in cultures containing 8 μg/ml amikacin was significantly inhibited by the addition of 2 μM Zn(2+) in complex with the ionophore pyrithione (ZnPT).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / antagonists & inhibitors*
  • Acinetobacter baumannii / enzymology*
  • Amikacin / pharmacology*
  • Anti-Bacterial Agents / pharmacology
  • Chlorides / pharmacology*
  • Drug Resistance, Bacterial / drug effects
  • Escherichia coli / enzymology*
  • Ionophores / pharmacology
  • Microbial Sensitivity Tests
  • Pyridines / pharmacology
  • Thiones / pharmacology
  • Zinc Compounds / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Chlorides
  • Ionophores
  • Pyridines
  • Thiones
  • Zinc Compounds
  • pyrithione
  • Amikacin
  • zinc chloride
  • Acetyltransferases
  • aminoglycoside N(6')-acetyltransferase