Abstract
Lynch syndrome was described over a century ago but information on the medical consequences and optimal management of this disorder continue to amass and evolve. This brief overview highlights the gene-specific and site-specific cancer penetrance and management options for those with Lynch syndrome.
Publication types
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Historical Article
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Review
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Video-Audio Media
MeSH terms
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Animals
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Biomarkers, Tumor / genetics
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Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology
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Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
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Colorectal Neoplasms, Hereditary Nonpolyposis / history
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Colorectal Neoplasms, Hereditary Nonpolyposis / pathology
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Colorectal Neoplasms, Hereditary Nonpolyposis / therapy*
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Genetic Predisposition to Disease
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Heredity
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History, 20th Century
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History, 21st Century
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Humans
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Molecular Diagnostic Techniques
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Pedigree
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Phenotype
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Predictive Value of Tests
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Prevalence
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Risk Factors
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Treatment Outcome