Abstract
In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aluminum Compounds / chemistry
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Apoptosis / drug effects
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Biofilms / drug effects
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Biofilms / growth & development
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Calcium Compounds / chemistry
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Caspase 3 / metabolism
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Cell Adhesion / drug effects
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Cells, Cultured
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Ceramics / chemistry
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Ceramics / pharmacology*
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Coated Materials, Biocompatible / chemistry
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Coated Materials, Biocompatible / pharmacology*
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Enzyme Activation / drug effects
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Escherichia coli / drug effects
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Escherichia coli / physiology
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Humans
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Mesenchymal Stem Cells / drug effects
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Mesenchymal Stem Cells / enzymology
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Microbial Viability / drug effects*
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Microscopy, Electron, Scanning
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Microscopy, Electron, Transmission
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Oxides / chemistry
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Silicates / chemistry
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Sodium Compounds / chemistry
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Sodium Hydroxide / chemistry
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Surface Properties
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Thermography
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Time Factors
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X-Ray Diffraction
Substances
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Aluminum Compounds
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Anti-Bacterial Agents
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Calcium Compounds
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Coated Materials, Biocompatible
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Oxides
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Silicates
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Sodium Compounds
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nepheline
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soda lime
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Sodium Hydroxide
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Glass ceramics
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Caspase 3