More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration

Neuron. 2014 Aug 20;83(4):771-87. doi: 10.1016/j.neuron.2014.08.005.

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / physiopathology
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Apolipoproteins E / metabolism
  • Central Nervous System / growth & development
  • Central Nervous System / metabolism
  • Central Nervous System / physiology*
  • Central Nervous System / physiopathology
  • Endocytosis / physiology
  • Endosomes / metabolism
  • Humans
  • Models, Neurological
  • Nerve Degeneration / physiopathology*
  • Neurodegenerative Diseases / physiopathology*
  • Peripheral Nervous System / physiology
  • Receptors, LDL / physiology*
  • Synaptic Transmission / physiology

Substances

  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Receptors, LDL