Somatic loss of polycystic disease genes contributes to the formation of isolated and polycystic liver cysts

Gut. 2015 Apr;64(4):688-90. doi: 10.1136/gutjnl-2014-308062. Epub 2014 Sep 26.

Authors

Manoe J Janssen¹, Jody Salomon¹, Wybrich R Cnossen¹, Carsten Bergmann², Rolph Pfundt³, Joost P H Drenth¹

Affiliations

¹ Department of Gastroenterology & Hepatology, Radboudumc, Institute for Genetic and Metabolic Diseases, Nijmegen, The Netherlands.
² Department of Bioscientia, Center for Human Genetics, Ingelheim, Germany Renal Division, Department of Medicine, University Freiburg Medical Center, Freiburg, Germany.
³ Department of Human Genetics, Radboudumc, Institute for Genetic and Metabolic Diseases, Nijmegen, The Netherlands.

PMID: 25260921
DOI: 10.1136/gutjnl-2014-308062

No abstract available

Keywords: BILIARY EPITHELIUM; DNA DAMAGE; HEPATOBILIARY DISEASE; LIVER; MOLECULAR GENETICS.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cysts / genetics*
Female
Humans
Liver Diseases / genetics*
Loss of Heterozygosity*
Male
Middle Aged

Supplementary concepts

Polycystic liver disease