Ultrasensitive nanoparticle detection holds great potential for early-stage diagnosis of human diseases and for environmental monitoring. In this work, we report for the first time, to our knowledge, single nanoparticle detection by monitoring the beat frequency of split-mode Raman lasers in high-Q optical microcavities. We first demonstrate this method by controllably transferring single 50-nm-radius nanoparticles to and from the cavity surface using a fiber taper. We then realize real-time detection of single nanoparticles in an aqueous environment, with a record low detection limit of 20 nm in radius, without using additional techniques for laser noise suppression. Because Raman scattering occurs in most materials under practically any pump wavelength, this Raman laser-based sensing method not only removes the need for doping the microcavity with a gain medium but also loosens the requirement of specific wavelength bands for the pump lasers, thus representing a significant step toward practical microlaser sensors.
Keywords: label free; mode splitting; optical microcavity; optical sensor; stimulated Raman scattering.