eRNAs lure NELF from paused polymerases

Brian S Plosky

doi:10.1016/j.molcel.2014.09.016

eRNAs lure NELF from paused polymerases

Mol Cell. 2014 Oct 2;56(1):3-4. doi: 10.1016/j.molcel.2014.09.016.

Author

Brian S Plosky¹

Affiliation

¹ Molecular Cell, Cell Press, 600 Technology Square, 5th Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.

PMID: 25280099
DOI: 10.1016/j.molcel.2014.09.016

Abstract

RNAs transcribed from enhancers (eRNAs) have been linked to enhancer function. In this issue of Molecular Cell, Schaukowitch et al. (2014) show that upon activation, eRNAs can bind NELF and are necessary for its transient removal from promoters to release paused RNA polymerase II and drive expression of immediate-early genes in neurons.

Publication types

Comment

MeSH terms

Animals
Gene Expression Regulation / physiology*
Models, Genetic*
RNA, Long Noncoding / physiology*
Transcription Factors / physiology*

Substances

NELF protein, mouse
RNA, Long Noncoding
Transcription Factors