Dermoscopy, reflectance confocal microscopy and histopathology of a melanoma in situ from an individual homozygous for GSTP1*105Val/MC1R*92Met

Parastoo Banan; Katie J Lee; Phil McClenahan; Kasturee Jagirdar; Richard A Sturm; H Peter Soyer

doi:10.1111/ajd.12250

Dermoscopy, reflectance confocal microscopy and histopathology of a melanoma in situ from an individual homozygous for GSTP1105Val/MC1R92Met

Australas J Dermatol. 2016 Feb;57(1):64-7. doi: 10.1111/ajd.12250. Epub 2014 Oct 10.

Authors

Parastoo Banan¹, Katie J Lee¹, Phil McClenahan¹, Kasturee Jagirdar^{1

2}, Richard A Sturm^{1

2}, H Peter Soyer¹

Affiliations

¹ Dermatology Research Centre, School of Medicine, Translational Research Institute.
² Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.

PMID: 25302828
DOI: 10.1111/ajd.12250

Abstract

Glutathione S-transferase 1 is an enzyme involved in the detoxification of reactive oxygen species, and the rs1695*Val polymorphism has been proposed as a melanoma-associated variant with significant effect. We report a case of malignant melanoma in an individual homozygous for the rs1695*Val variant and discuss the non-invasive and histopathological tools used in diagnosis.

Keywords: GSTP1; RCM; dermoscopy; melanoma; regressive melanoma in situ; skin microbiopsy.

Publication types

Case Reports

MeSH terms

Aged
Dermoscopy
Glutathione S-Transferase pi / genetics*
Homozygote
Humans
Male
Melanoma / diagnostic imaging
Melanoma / genetics*
Melanoma / pathology*
Microscopy, Confocal
Neoplasms, Second Primary / diagnostic imaging
Neoplasms, Second Primary / genetics*
Neoplasms, Second Primary / pathology*
Skin Neoplasms / diagnostic imaging
Skin Neoplasms / genetics*
Skin Neoplasms / pathology*

Substances

GSTP1 protein, human
Glutathione S-Transferase pi