Sphingolipids in the DNA damage response

Adv Biol Regul. 2015 May:58:38-52. doi: 10.1016/j.jbior.2014.11.001. Epub 2014 Nov 18.

Abstract

Recently, sphingolipid metabolizing enzymes have emerged as important targets of many chemotherapeutics and DNA damaging agents and therefore play significant roles in mediating the physiological response of the cell to DNA damage. In this review we will highlight points of connection between the DNA damage response (DDR) and sphingolipid metabolism; specifically how certain sphingolipid enzymes are regulated in response to DNA damage and how the bioactive lipids produced by these enzymes affect cell fate.

Keywords: Ceramide; DNA damage; Sphingosine; Sphingosine 1-phosphate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / metabolism
  • Ataxia Telangiectasia Mutated Proteins / genetics
  • Ataxia Telangiectasia Mutated Proteins / metabolism
  • Cell Cycle Checkpoints / genetics*
  • DNA / genetics
  • DNA / metabolism*
  • DNA Damage
  • DNA Repair*
  • Gene Expression Regulation
  • Humans
  • Lipid Metabolism / genetics
  • Lysophospholipids / metabolism*
  • Signal Transduction
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Apoptosis Regulatory Proteins
  • Lysophospholipids
  • Tumor Suppressor Protein p53
  • sphingosine 1-phosphate
  • DNA
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Sphingosine