More division of labor at the eukaryotic replication fork

Brian S Plosky

doi:10.1016/j.molcel.2014.11.004

More division of labor at the eukaryotic replication fork

Mol Cell. 2014 Nov 20;56(4):467-8. doi: 10.1016/j.molcel.2014.11.004. Epub 2014 Nov 20.

Author

Brian S Plosky¹

Affiliation

¹ Molecular Cell, Cell Press, 600 Technology Square, 5(th) Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.

PMID: 25459878
DOI: 10.1016/j.molcel.2014.11.004

Abstract

Our understanding of the dynamics of replication fork-associated protein strand specificity is based largely on genetic or in vitro approaches. Yu et al. (2014) present eSPAN, a ChIP approach that reveals differences between protein abundance on nascent leading and lagging strands.

Publication types

Comment

MeSH terms

DNA Replication*
DNA, Fungal / biosynthesis*
Proliferating Cell Nuclear Antigen / metabolism*
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae Proteins / metabolism*

Substances

DNA, Fungal
Proliferating Cell Nuclear Antigen
Saccharomyces cerevisiae Proteins