MicroRNA-124 modulates social behavior in frontotemporal dementia

Andrew E Arrant; Erik D Roberson

doi:10.1038/nm.3768

MicroRNA-124 modulates social behavior in frontotemporal dementia

Nat Med. 2014 Dec;20(12):1381-3. doi: 10.1038/nm.3768.

Authors

Andrew E Arrant¹, Erik D Roberson¹

Affiliation

¹ Center for Neurodegeneration and Experimental Therapeutics, Departments of Neurology and Neurobiology, Birmingham, Alabama, USA.

PMID: 25473917
DOI: 10.1038/nm.3768

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.

Publication types

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MeSH terms

Animals
Behavior, Animal*
Endosomal Sorting Complexes Required for Transport / genetics*
Frontal Lobe / metabolism*
Frontotemporal Dementia / genetics*
MicroRNAs / metabolism*
Nerve Tissue Proteins / genetics*
Neurons / metabolism*
Receptors, AMPA / metabolism*
Social Behavior*

Substances

CHMP2B protein, mouse
Endosomal Sorting Complexes Required for Transport
MicroRNAs
Mirn124 microRNA, mouse
Nerve Tissue Proteins
Receptors, AMPA