MicroRNA-124 modulates social behavior in frontotemporal dementia

Nat Med. 2014 Dec;20(12):1381-3. doi: 10.1038/nm.3768.

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.

Publication types

  • Comment

MeSH terms

  • Animals
  • Behavior, Animal*
  • Endosomal Sorting Complexes Required for Transport / genetics*
  • Frontal Lobe / metabolism*
  • Frontotemporal Dementia / genetics*
  • MicroRNAs / metabolism*
  • Nerve Tissue Proteins / genetics*
  • Neurons / metabolism*
  • Receptors, AMPA / metabolism*
  • Social Behavior*

Substances

  • CHMP2B protein, mouse
  • Endosomal Sorting Complexes Required for Transport
  • MicroRNAs
  • Mirn124 microRNA, mouse
  • Nerve Tissue Proteins
  • Receptors, AMPA