Abstract
Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.
MeSH terms
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Animals
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Behavior, Animal*
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Endosomal Sorting Complexes Required for Transport / genetics*
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Frontal Lobe / metabolism*
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Frontotemporal Dementia / genetics*
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MicroRNAs / metabolism*
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Nerve Tissue Proteins / genetics*
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Neurons / metabolism*
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Receptors, AMPA / metabolism*
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Social Behavior*
Substances
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CHMP2B protein, mouse
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Endosomal Sorting Complexes Required for Transport
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MicroRNAs
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Mirn124 microRNA, mouse
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Nerve Tissue Proteins
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Receptors, AMPA