BK virus nephropathy in a pediatric patient after hematopoietic stem cell transplantation

M Aksenova; V Tsetlina; E Gutovskaya; A Mitrofanova; D Balashov; A Maschan

doi:10.1111/petr.12411

BK virus nephropathy in a pediatric patient after hematopoietic stem cell transplantation

Pediatr Transplant. 2015 Feb;19(1):E29-32. doi: 10.1111/petr.12411. Epub 2014 Dec 7.

Authors

M Aksenova¹, V Tsetlina, E Gutovskaya, A Mitrofanova, D Balashov, A Maschan

Affiliation

¹ Nephrology Department, Research and Clinical Institute for Pediatrics, the Pirogov Russian National Research Medical University, Moscow, Russia; Department of Clinical Diagnostics, the Rogachev Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

PMID: 25484248
DOI: 10.1111/petr.12411

Abstract

We report the case of a seven-yr-old Caucasian girl who presented with progressive deterioration of renal function 13 months after HSCT for myelodysplastic syndrome. BK virus nephropathy was suspected and confirmed. After reduction of immunosuppression and treatment with IVIG, leflunomide, ciprofloxacin, and cidofovir, clearance of BK virus from blood was achieved, and further progression or renal failure was prevented. We believe that BK virus nephropathy should be considered in cases of renal function deterioration in all immunocompromised patients.

Keywords: BK polyomavirus; BK virus nephropathy; hematopoietic stem cell transplantation; renal insufficiency.

Publication types

Case Reports

MeSH terms

BK Virus*
Child
Female
Hematopoietic Stem Cell Transplantation*
Humans
Kidney Diseases / diagnosis*
Kidney Diseases / virology*
Polyomavirus Infections / diagnosis*
Postoperative Complications / diagnosis*
Postoperative Complications / virology*
Tumor Virus Infections / diagnosis*