Purpose: Perfusion computed tomography imaging (PCT) is a robust, reproducible, widely accessible non-invasive method. The objective of our study was to assess whether prospectively collected pretreatment PCT parameters and volumetric measurements of locoregionally advanced squamous cell carcinoma (SCCA) of the oral cavity, oropharynx and hypopharynx could predict the response to concomitant chemoradiotherapy with cisplatin Methods: Pretreatment contrast enhanced PCT was performed in 30 patients. Radiologic response criteria (RECIST) were used to evaluate tumor response. The correlation and predictive value of baseline PCT parameters and tumor volume were examined by using the Student's t-test, Pearson's correlation coefficient and receiver operating characteristic (ROC) curves.
Results: Baseline tumor volume, blood volume (BV) and blood flow (BF) were significantly higher in responders than in non-responders. Permeability surface (PS) did not show any significant difference between the two groups. Pretreatment tumor volume correlated with baseline BV (r=-0.4; p=0.01). Pretreatment tumor volume had 100% sensitivity and specificity (p=0.0001) and BV and BF also showed satisfactory sensitivity and specificity (100% and 65%, p=0.0002; 78% and 80.2%, p=0.01, respectively) for prediction of tumor response to concomitant chemoradiotherapy with cisplatin.
Conclusion: Baseline BV, BF and tumor volume values were significantly different between responders and non-responders and could predict response to concomitant chemoradiotherapy with cisplatin in locoregionally advanced SCCA.