Vascular-promoting therapy reduced tumor growth and progression by improving chemotherapy efficacy

Esther Bridges; Adrian L Harris

doi:10.1016/j.ccell.2014.12.009

Vascular-promoting therapy reduced tumor growth and progression by improving chemotherapy efficacy

Cancer Cell. 2015 Jan 12;27(1):7-9. doi: 10.1016/j.ccell.2014.12.009.

Authors

Esther Bridges¹, Adrian L Harris²

Affiliations

¹ Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
² Department of Medical Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address: aharris.lab@oncology.ox.ac.uk.

PMID: 25584889
DOI: 10.1016/j.ccell.2014.12.009

Abstract

In this issue of Cancer Cell, Wong and colleagues describe a novel approach of increasing the number of functional blood vessels in tumors using a low-dose therapy regimen of Cilengtide and Verapamil. This method enhanced gemcitabine delivery, uptake, and metabolism within tumor cells to reduce tumor growth and progression.

Publication types

Comment

MeSH terms

Animals
Antimetabolites, Antineoplastic / administration & dosage*
Carcinoma, Lewis Lung / drug therapy*
Carcinoma, Lewis Lung / pathology*
Deoxycytidine / administration & dosage
Deoxycytidine / analogs & derivatives*
Gemcitabine
Humans
Pancreatic Neoplasms / drug therapy*
Snake Venoms / administration & dosage*
Verapamil / administration & dosage*

Substances

Antimetabolites, Antineoplastic
Snake Venoms
Deoxycytidine
Cilengitide
Verapamil
Gemcitabine

Abstract

Publication types

MeSH terms

Substances

Grants and funding