Can circulating tumor cells predict resistance in metastatic breast cancer?

Clin Cancer Res. 2015 Jun 1;21(11):2421-3. doi: 10.1158/1078-0432.CCR-14-2967. Epub 2015 Feb 2.

Abstract

Circulating tumor cell (CTC) enumeration provides prognostic but not predictive information for chemotherapy in metastatic breast cancer. Because CTC measurement is reproducible and allows molecular profiling, an assay to assess endocrine resistance was developed. Whether this CTC-based assay can be used to reliably select endocrine therapy must be tested.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Breast Neoplasms / genetics*
  • Female
  • Humans
  • Ki-67 Antigen / genetics*
  • Neoplastic Cells, Circulating / pathology*
  • Proto-Oncogene Proteins c-bcl-2 / genetics*
  • Receptor, ErbB-2 / genetics*
  • Receptors, Estrogen / genetics*

Substances

  • Ki-67 Antigen
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Estrogen
  • Receptor, ErbB-2