A new role for an old enemy

Elife. 2015 Feb 10:4:e06424. doi: 10.7554/eLife.06424.

Abstract

Drugs that change the shape of AKT, a protein kinase that promotes tumor growth, may be more effective than drugs that only target its enzymatic activity.

Keywords: AKT; PI3K; cell biology; cell survival; human; human biology; kinase inhibitor; kinase-independent; medicine; mouse; oncogenic.

Publication types

  • Comment

MeSH terms

  • Cell Survival*
  • Humans
  • Melanoma / pathology*
  • Proto-Oncogene Proteins c-akt / metabolism*

Substances

  • Proto-Oncogene Proteins c-akt