Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent

Christopher G Kanakry; Sudipto Ganguly; Leo Luznik

doi:10.4161/2162402X.2014.974393

Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent

Oncoimmunology. 2015 Mar 20;4(3):e974393. doi: 10.4161/2162402X.2014.974393. eCollection 2015 Mar.

Authors

Christopher G Kanakry¹, Sudipto Ganguly¹, Leo Luznik¹

Affiliation

¹ Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine ; Baltimore, MD, USA.

Abstract

In two recent publications, we demonstrated that after allogeneic stimulation, regulatory T cells (T_regs) increase expression of aldehyde dehydrogenase (ALDH), the major in vivo mechanism of cyclophosphamide detoxification, thereby becoming cyclophosphamide resistant. Differential ALDH expression may explain why cyclophosphamide has pro- and anti-inflammatory effects that are temporally and contextually dependent.

Keywords: aldehyde dehydrogenase, ALDH, allogeneic, BMT, cyclophosphamide, post-transplantation cyclophosphamide, regulatory T cell, tolerance, Treg.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Abstract

Publication types

Grants and funding